（現 職） 教授
（生年月） 1950年１月
（専門分野）
人体病理学、免疫組織化学、ムチンコア蛋白の遺伝子発現
| （氏 名） 米澤傑
（現 職） 教授 （生年月） 1950年１月 （専門分野） 人体病理学、免疫組織化学、ムチンコア蛋白の遺伝子発現 |
|
syoneza@m2.kufm.kagoshima-u.ac.jp
鹿児島大学大学院医学研究科博士課程 外科系専攻 1979年3月単位取得後退学
医学博士・鹿児島大学・1980年1月
日本病理学会（評議員）、日本癌学会、日本組織細胞科学会（評議員）、米国癌学会
ヒト癌の産生するムチン抗原と癌の生物学的悪性度の関連性抗血液凝固性蛋白「トロンボモジュリン」の扁平上皮癌における発現
（原著論文）2004.8.25現在
Iino S, Abeyama K, Kwahara K, Yamakuchi M, Hashiguchi T, Matsukita S, Yonezawa S, Taniguchi S, Nakata M, Takao S, Aikou T, Maruyama I:The antimetastaic role of thrombomodulin expression in islet cell-derived tumors and its diagnostic value.Clin. Cancer Res., in press.
Sasaki M, Nomoto M, Yonezawa S, Nakagawa M, Sakuragi N, Fujimoto S, Carroll R P, Dahiya R:Distribution of a single nucleotide polymorphism on codon 211 of the androgen receptor gene and its correlation with human renal cell cancer in japanese patients.Biochem. Biophys.Res. Commun., in press.
Hruban R H, Takaori K, Klimstra D S, Adsay N V, Albores-Saavedra J, Biankin A V, Biankin S A, Compton C, Fukushima N, Furukawa T, Goggins M, Kato Y, Kloppel G, Longnecker D S, Luttges J, Maitra A, Offerhaus G J, Shimizu M, Yonezawa S:An illustrated consensus on the classification of pancreatic intraepithelial neoplasia and intraductal papillary mucinous neoplasms.Am. J. Surg. Pathol. 28: 977-987, 2004
Su L, Hasui K, Sueyoshi K, Matsushita S, Tsuyama S, Kim S B, Kim B J, Higashi M, Yonezawa S and Murata F:Expression of mucins in the human fetal and neonatal stomach.Acta Histochem. Cytochem. 37: 163-172, 2004
Hamada T, Matsukita S, Goto M, Kitajima S, Batra S K, Irimura T, Sueyoshi K, Sugihara K, Yonezawa S: Mucin Expression in Pleomorphic Adenoma of Salivary Gland: A Potential Role of MUC1 as a Marker to Predict a Recurrence. Journal of Clinical Pathology, in press.
Koriyama C, Kitajima S, Nomoto M, Sueyoshi K, Itoh T, Eizuru Y, Yonezawa S, and Akiba S: Loss of P16/CDKN2A protein in Epstein-Barr virus-associated gastric carcinoma. Oncology (Basal), in press.
Sasaki M, Tanaka Y, Okino ST, Nomoto M, Yonezawa S, Nakagawa M, Fujimoto S, Sakuragi N, Dahiya R: Polymorphisms of the CYP1B1 gene as risk factors for human renal cell cancer. Clinical Cancer Reserch 10: 2015-9. 2004
Shibahara H, Tamada S, Goto M, Oda K, Nagino M, Nagasaka T, Batra S K, Hollingsworth M A, Imai K, Nimura Y, Yonezawa S: Pathologic features of mucin-producing bile duct tumors: two histopathological categories as counterparts of pancreatic intraductal papillary-mucinous neoplasms. American Journal of Surgical Pathology 28: 327-338. 2004
Tsutsumida H, Goto M, Kitajima S, Kubota I, Hirotsu Y, Yonezawa S: Combined status of MUC1 mucin and surfactant apoprotein A expression can predict the outcome of patients with small size lung adenocarcinoma. Histopathology 44: 147-155, 2004
Shibahara H, Tamada S, Higashi M, Goto M, Batra S K, Hollingsworth M A, Imai K, Yonezawa S: MUC4 is a novel prognostic factor of intrahepatic cholangiocarcinoma-mass forming type. Hepatology 39: 220-29, 2004
Tsuyama S, Matsusita S, Nonaka S, Yonezawa S, Murata F:Cytochemistry of gastric parietal cells with high-pressure freezing followed by freeze-substitution.J. Electron Microsc.52:145-151, 2003
Hinoda Y, Ikematsu Y, Horinouchi M, Sato S, Yamamoto K, Nakano T, Fukui M, Suehiro Y, Hamanaka Y, Nishikawa Y, Kida H, Waki S, Oka M, Imai K, Yonezawa S: Increased expression of MUC1 in advanced pancreatic cancer. Journal of Gastroenterology 38: 1162-1166, 2003
Horinouchi M, Nagata K, Nakamura A, Goto M, Takao S, Sakamoto M, Fukushima N, Miwa A, Irimura T, Imai K, Sato E, Yonezawa S: Expression of different glycoforms of membrane mucin (MUC1) and secretory mucin (MUC2, MUC5AC and MUC6) in pancreatic neoplasms. Acta Histochemica et Cytochemica, 36: 443-453, 2003
Matsukita S, Nomoto M, Kitajima S, Tanaka S, Goto M, Irimura T, Kim Y S, Sato E, Yonezawa S : Expression of mucins (MUC1, MUC2, MUC5AC and MUC6) in mucinous carcinoma of the breast: comparison with invasive ductal carcinoma. Histopathology 42: 26-36, 2003
Ribeiro-Filho LA, Franks J, Sasaki M, Shiina H, Li LC, Nojima D, Arap S, Carroll P, Enokida H, Nakagawa M, Yonezawa S, Dahiya R: CpG hypermethylation of promoter region and inactivation of E-cadherin gene in human bladder cancer. Molecular Carcinogenesis 34: 187-198, 2002
Seko A, Nagata K, Yonezawa S, Yamashita K: Ectopic expression of a GalNAc 6-O-sulfotransferase, GlcNAc6ST-2, in colonic mucinous adenocarcinoma. Glycobiology 12: 379-388, 2002
Taki C, Kitajima S, Sueyoshi K, , Yonezawa S, Tanaka S, Sakoda K, Irimura T, Sato E, Goto M: MUC1 mucin expression in follicular dendritic cells and lymphoepithelial lesions of gastric mucosa-associated lymphoid tissue lymphoma. Pathology International 52: 691-701, 2002
Tamada S, Goto M, Nomoto M, Nagata K, Shimizu T, Tanaka S, Sakoda K, Imai K, Yonezawa S: Expression of MUC1 and MUC2 mucins in extrahepatic bile duct carcinomas: Its relationship with tumor progression and prognosis. Pathology International 52: 713-723, 2002
Seko A, Nagata K, Yonezawa S, Yamashita K: Down-regulation of Gal 3-O-sulfotransferase-2 (Gal3ST-2) Expression in Human Colonic Non-mucinous Adenocarcinoma. Japanese Journal of Cancer Research 93: 507-515, 2002
Yoshii N, Kitajima S, Yonezawa S, Matsukita S, Setoyama M, Kanzaki T: Expression of mucin core proteins in extramammary Paget’s disease. Pathology International 52: 390-399, 2002
Nakamura A, Horinouchi M, Goto M, Nagata K, Sakoda K, Takao S, Imai K, Kim YS, Sato E, Yonezawa S: New classification of pancreatic intraductal papillary-mucinous tumour by mucin expression: its relationship with potential for malignancy. Journal of Pathology 197: 201-210, 2002
Tsuji M, Goto M, Uehara F, Kaneko A, Sawai J, Yonezawa S, Ohba N: Photoreceptor cell differentiation in retinoblastoma demonstrated by a new immunohistochemical marker mucin-like glycoprotein associated with photoreceptor cells (MLGAPC). Histopathology 40:180-186, 2002
Wang F, Goto M, Kim YS, Higashi M, Imai K, Sato E, Yonezawa S: Altered GalNAc-α-2,6-Sialylation Compartments for Mucin-Associated Sialyl-Tn Antigen in Colorectal Adenoma and Adenocarcinoma. The Journal of Histochemistry & Cytochemistry 49: 1581-1591, 2001.
Li A, Yonezawa S, Matsukita S, Hasui K, Goto M, Tanaka S, Imai K, Sato E.: Comparative study for histology, proliferative activity, glycoproteins, and p53 protein between old and recent colorectal adenomas in Japan. Cancer Letters 170: 45-52, 2001.
Seko A., Sumiya J., Yonezawa S., Nagata K., Yamashita K.: Biochemical differences between two types of N-acetylglucosamine:→6sulfotransferases in human colonic adenocarcinomas and the adjacent normal mucosa: specific expression of a GlcNAc:→6sulfotransferase in mucinous adenocarcinoma. Glycobiology 10: 919-929, 2000.
Kawachi, K., Matsushita, Y., Yonezawa, S., Nakano, S., Shirao, K., Natsugoe, S., Sueyoshi, K., Aikou, T., Sato, E.: Galectin-3 expression in various thyroid neoplasms and its possible role in metastasis formation. Human Pathology 31: 428-433, 2000
Ogawa, H., Yonezawa, S., Maruyama, I. Matsushita, Y., Tezuka, Y., Toyoyama, H., Yanagi, M., Matsumoto, H., Nishijima, H., Shimotakahara, T., Aikou, T., Sato, E.: Expression of thrombomodulin in squamous cell carcinoma of the lung: its relationship to lymph node metastasis and prognosis of the patients. Cancer Letters 149: 95-103, 2000.
Higashi M., Yonezawa S., Ho J.J.L., Tanaka S., Irimura T., Kim Y.S., Sato E.: Expression of MUC1 and MUC2 mucin antigens in intrahepatic bile duct tumors: Its relationship with a new morphological classification of cholangiocarcinoma. Hepatology 30: 1347-1355, 1999.
Li A., Hasui K., Yonezawa S., Tanaka S., Sato E.: Immunohistochemical analysis of pericryptal fibroblast sheath and proliferating epithelial cells in human colorectal adenomas and carcinomas with adenoma components. Pathology International 49: 426-434, 1999.
Sagara M., Yonezawa S., Nagata K., Tezuka Y., Natsugoe S., Xing P.-X., McKenzie I. F. C., Aikou T., Sato E.: Expression of mucin 1 (MUC1) in esophageal squamous cell carcinoma: Its relationship with prognosis. International Journal of Cancer, 84: 251-257, 1999.
Yonezawa S., Horinouchi M., Osako M., Kubo M., Takao S., Arimura Y., Nagata K., Tanaka S., Sakoda K., Aiko T., Sato E.: Gene expression of gastric type mucin (MUC5AC) in pancreatic tumors: Its relationship with bilological behavior of the tumors. Pathology International 49: 45-54, 1999.
Utsunomiya T., Yonezawa S., Sakamoto H., Kitamura H., Hokita S., Aiko T., Tanaka S., Irimura T., Kim Y. S., Sato E.: Expression of MUC1 and MUC2 mucins in gastric carcinomas: Its relationship with the prognosis of the patients. Clinical Cancer Research 4: 2605-2614, 1998.
Yonezawa S., Taira M., Osako M., Kubo M., Tanaka S., Sakoda K., Takao S., Aiko T., Yamamoto M., Irimura T., Kim Y. S., Sato E.: MUC-1 mucin expression in invasive areas of intraductal papillary mucinous tumors of the pancreas. Pathology International 48: 319-322, 1998.
Matsushita Y., Yoshiie K., Imamura Y., Ogawa H., Imamura H., Takao S., Yonezawa S., Aikou T., Maruyama I., Sato E.: A subcloned human esophageal squamous cell carcinoma cell line with low thrombomodulin expression showed increased invasiveness compared with a high thrombomodulin-expressing clone ― thrombomodulin as a possible candidate for an adhesion molecule of squamous cell carcinoma. Cancer Letters 127: 195-201, 1998.
Uehara F., Yonezawa S., Sato E., Ohba N.: Glycopathological study of eyelid tumors and pseudotumors. Japanese Journal of Ophthalmology 41: 362-369, 1997.
Sakamoto H., Yonezawa S., Utsunomiya T., Tanaka S., Kim Y. S., Sato E.: Mucin antigen expression in gastric carcinomas of young and old adults. Human Pathology 28: 1056-1065, 1997.
Tabata M., Sugihara K., Yonezawa S., Yamashita S., Maruyama I.: An immunohistochemical study of thrombomodulin in oral squamous cell carcinoma and its association with invasive and metastatic potential. Journal of Oral Pathology & Medicine 26: 258-264, 1997.
Yonezawa S., Sueyoshi K., Nomoto M., Kitamura H., Nagata K., Arimura Y., Tanaka S., Hollingsworth M. A., Siddiki B., Kim Y. S., Sato E.: MUC2 gene expression is found in noninvasive tumors but not in invasive tumors of the pancreas and liver: Its close relationship with prognosis of the patients. Human Pathology 28: 344-352, 1997.
Itoh T., Yonezawa S., Nomoto M., Ueno K., Kim Y. S., Sato E.: Expression of mucin antigens and Lewis X-related antigens in carcinomas and dysplasia of the pharynx and larynx. Pathology International 46: 646-655, 1996.
Seko A., Ohkura T., Kitamura H., Yonezawa S., Sato E., Yamashita K.: Quantitative differences in GlcNAc:β1→3 and GlcNAc:β1→4 galactosyltransferase activities between human colonic adenocarcinomas and normal colonic mucosa. Cancer Research 56: 3468-3473, 1996.
Kitamura H., Yonezawa S., Tanaka S., Kim Y. S., Sato E.: Expression of mucin carbohydrates and core proteins in carcinomas of the ampulla of Vater: Their relationship to prognosis. Japanese Journal of Cancer Research 87: 631-640, 1996.
Tezuka Y., Yonezawa S., Maruyama I., Matsushita Y., Shimizu T., Obama H., Sagara M., Shirao K., Kusano C., Natsugoe S., Yoshinaka H., Baba M., Fukumoto T., Aikou T., Sato E.: Expression of thrombomodulin in esophageal squamous cell carcinoma and its relationship to lymph node metastasis. Cancer Research 55: 4196-4200, 1995.
Yamashita K., Yonezawa S., Tanaka S., Shirahama H., Sakoda K., Imai K., Xing P.-X., McKenzie I. F. C., Hilkens J., Kim Y. S., Sato E.: Immunohistochemical study of mucin carbohydrates and core proteins in hepatolithiasis and cholangiocarcinoma. International Journal of Cancer 55: 82-91, 1993.
Osako M., Yonezawa S., Siddiki B., Huang J., Ho J. J. L., Kim Y. S., Sato E.: Immunohistochemical study of mucin carbohydrates and core proteins in human pancreatic tumors. Cancer 71: 2191-2199, 1993.
Yonezawa S., Tachikawa T., Shin S., Sato E.: Sialosyl-Tn antigen: Its distribution in normal human tissues and expression in adenocarcinomas. American Journal of Clinical Pathology 98: 167-174, 1992.
Yonezawa S., Byrd J. C., Dahiya R., Ho J. J. L., Gum J. R., Griffiths B., Swallow D. M., Kim Y. S.: Differential mucin gene expression in human pancreatic and colon cancer cells. The Biochemical Journal 276: 599-605, 1991.
Yonezawa S., Maruyama I., Sakae K., Igata A., Majerus P. W., Sato E.: Thrombomodulin as a marker for vascular tumors: Comparative study with factor VIII and Ulex europaeus I lectin. American Journal of Clinical Pathology 88: 405-411, 1987.
Yonezawa S., Irisa S., Nakamura T., Uemura S., Otsuji Y., Ohi Y., Sato E.: Deposition ofα1-antitrypsin and loss of glycoconjugate carrying Ulex europaeus agglutinin-I binding sites in the glomerular sclerotic process: Phenomena common to chronic pyelonephritis and chronic diffuse proliferative glomerulonephritis. Nephron 33: 38-43, 1983.
Yonezawa S., Nakamura T., Tanaka S., Sato E.: Glycoconjugate with Ulex europaeus agglutinin-I-binding sites in normal mucosa, adenoma, and carcinoma of the human large bowel. Journal of the National Cancer Institute 69: 777-785, 1982.
Miyauchi T., Yonezawa S., Takamura T., Chiba T., Tejima S., Ozawa M., Sato E., Muramatsu T.: A new fucosyl antigen expressed on colon adenocarcinoma and embryonal carcinoma cells. Nature 299: 168-169, 1982.
Yonezawa S., Sato E., Okamoto K.: Polyanion, immunoprotein and proteinase inhibitor in ischemic glomerular change. Nephron 28: 105-111, 1981.
Yonezawa S.: Immunopathology of the glomerular changes in chronic pyelonephritis. Acta Pathologica Japonica（現在のPathology International） 29: 677-685, 1979.
（総説）
米澤 傑、野元三治、永田耕治： 病理医のための組織学の基礎 第７回 膵 (外分泌). 病理と臨床 22:403-408, 2004.
米澤 傑、野元 三治、東 美智代： 病理診断における分子生物学第2部 診断への応用と展望 A. 腫瘍 8. 膵癌. 病理と臨床 臨時増刊号 22:147-155, 2004
米澤 傑、野元三治、永田耕治: 特殊染色を用いた消化管の病理診断 粘液形質の診断（2）粘液総論?：消化管におけるムチン染色. 臨牀消化器内科 18:1179-1187, 2003
米澤 傑、野元三治、永田耕治：特殊染色を用いた消化管の病理診断 粘液形質の診断（1）粘液総論?：ムチン-粘液の主成分-. 臨牀消化器内科 18: 741-752, 2003
Yonezawa S, Nakamura A, Horinouchi M, Sato E: The expression of several types of mucin is related to the biological behavior of pancreatic neoplasms. Journal of Hepatobiliary Pancreat Surgery 9: 328-341, 2002
村田長芳、上原文行、津山新一郎、蓮井和久、米澤 傑： 複合糖質の局在と機能． 細胞 34: 596-599, 2002
米澤 傑、堀之内 道子、中村 晃子： ムチンの発現様式からみた通常型膵管癌の組織発生 ― 膵管内乳頭腫瘍との対比 ―． 胆と膵 23 (3):187-194, 2002
米澤 傑： ヒト腫瘍におけるムチン抗原発現と腫瘍の生物学的悪性度との関連. 鹿児島市医報 39（3）：4-17、2000
米澤 傑： 膵癌に発現するムチンの特徴． 消化器科 30 (1): 70-79, 2000.
Yonezawa S., Sato E.: Expression of mucin antigens in human cancers and its relationship with malignancy potential. Pathology International 47: 813-830, 1997.
Matsushita Y., Yonezawa S., Nakamori S., Irimura T., Sato E.: Carbohydrate antigens aberrantly expressed in colorectal carcinoma. Critical Reviews in Oncology/Hematology 25: 27-54, 1997.
米澤 傑： 食道・肺の扁平上皮癌におけるトロンボモデュリンの発現とリンパ節転移に伴う発現の低下． リンパ学 19: 59-64, 1996.
米澤 傑： 消化器腫瘍におけるムチン抗原の発現． G. I. Research 4: 380-388, 1996.
米澤 傑： 大腸癌と腫瘍マーカー． 病理と臨床 13: 971-978, 1995.
Yonezawa S.: Application of immunohistochemistry for diagnosis of neoplasms: Mucin antigens expression and biological behavior of neoplasms. Acta Histochemica et Cytochemica 27: 561-566, 1994.
米澤 傑： がん細胞-血管内皮細胞接着：糖鎖抗原． Oncologia 26: 533-540, 1993.
佐藤 栄一，米沢 傑，北島 信一： 腎糸球体硬化過程における血液型物質の変化とα1-アンチトリプシンの関与． 病態生理 8: 1037-1039, 1989.
米澤 傑： 新しい抗血液凝固性蛋白“トロンボモジュリン”の生体内分布と疾患時の発現状況． 医学のあゆみ 147: 93, 1988.
米澤 傑，佐藤 栄一： レクチンの病理組織学への応用 ― 消化管腫瘍，血管性腫瘍の研究へのUEA-Iレクチンの応用を中心として ―． 細胞 20: 260-264, 1988.
（著書）
米澤 傑，後藤 正道： 看護のための最新医学講座（第24巻腫瘍の臨床）（分担執筆）， 腫瘍の病理．（今井 浩三編） pp 7-23，中山書店，東京，2001.
米澤 傑，佐藤 榮一： 日本人の病気と病理学（病理と臨床 第17巻 臨時増刊号） （分担執筆）， ヒト消化器癌の癌性変化とムチン抗原 ― とくに悪性度との関連 ― ． （「病理と臨床」常任編集委員会 編集） pp 267，文光堂，東京，1999.
松下 能文，有村 佳子，米澤 傑： [ 続] がんの浸潤・転移研究マニュアル ― 実験の手技と指針 ―（分担執筆），Ａ5．接着分子：転移関連糖鎖 １．糖鎖抗原の免疫組織化学的検出． （入村 達郎 責任編集） pp 122-125，金芳堂，東京，1997.
米澤 傑，有村 佳子： 免疫組織・細胞化学検査（臨床検査 39巻 11号，1995年 増刊号）（分担執筆）， I. 基礎と技術 ６．染色法 １） 酵素抗体法． （池田 康夫，覚道 健一，加藤 良平，坂本 穆彦 編集） pp 30-34，医学書院，東京，1995.
米澤 傑，佐藤 栄一： 免疫組繊化学（病理と臨床 第6巻 臨時増刊号）（分担執筆），４．レクチン組織化学およびその応用． （渡辺 慶一 編集） pp 34-41，文光堂，東京，1988.
佐藤 栄一，米澤 傑，中村 敬夫，松下 能文： マニュアル 実験組織化学（分担執筆），III．レクチン ４．消化管． （平野 寛，川生 明，横山 正夫 編著） pp 542-556，丸善株式会社，東京，1987.
