Moriya S, Yamashita A, Masukawa D, Kambe Y, Sakaguchi J, Setoyama H, Yamanaka A, Kuwaki T (2020) Involvement of supralemniscal nucleus (B9) 5-HT neuronal system in nociceptive processing: a fiber photometry study. Molecular brain 13: 14.

Nguyen TT, Kambe Y, Kurihara T, Nakamachi T, Shintani N, Hashimoto H, Miyata A (2020) Pituitary Adenylate Cyclase-Activating Polypeptide in the Ventromedial Hypothalamus Is Responsible for Food Intake Behavior by Modulating the Expression of Agouti-Related Peptide in Mice. Mol. Neurobiol.

Nguyen TT, Kambe Y, Miyata A (2020) Chronic royal jelly administration induced antidepressant-like effects through increased sirtuin1 and oxidative phosphorylation protein expression in the amygdala of mice. Current Molecular Pharmacology


Takasaki I, Ogashi H, Okada T, Shimodaira A, Hayakawa D, Watanabe A, Miyata A, Kurihara T, Gouda H, Toyooka N. Synthesis of a novel and potent small-molecule antagonist of PAC1 receptor for the treatment of neuropathic pain. Eur J Med Chem. 2019 Nov 19:111902. doi: 10.1016/j.ejmech.2019.111902.


Takasaki I, Nakamura K, Shimodaira A, Watanabe A, Du Nguyen H, Okada T, Toyooka N, Miyata A, Kurihara T. The novel small-molecule antagonist of PAC1 receptor attenuates formalin-induced inflammatory pain behaviors in mice. J Pharmacol Sci. 2018 Dec 1. pii: S1347-8613(18)30216-0. doi: 10.1016/j.jphs.2018.11.011.

神戸 悠輝, 栗原 崇, 宮田 篤郎. PACAPシグナリングによって駆動されるアストロサイト―ニューロン乳酸シャトルの中枢神経機能発現への寄与―. 2018 年 151 巻 6 号 p. 239-243

Takasaki I, Watanabe A, Yokai M, Watanabe Y, Hayakawa D, Nagashima R, Fukuchi M, Okada T, Toyooka N, Miyata A, Gouda H, Kurihara T. In Silico Screening Identified Novel Small-molecule Antagonists of PAC1 Receptor. J Pharmacol Exp Ther. 2018 Apr;365(1):1-8. doi: 10.1124/jpet.117.245415. Epub 2018 Jan 23.


神戸 悠輝、宮田篤郎. 大うつ病性障害におけるミトコンドリア機能障害とサーチュイン1の関与. 日本薬理学雑誌. 2017;150(4), 204-206

Aizawa F, Ogaki Y, Kyoya N, Nishinaka T, Nakamoto K, Kurihara T, Hirasawa A, Miyata A, Tokuyama S. The Deletion of GPR40/FFAR1 Signaling Damages Maternal Care and Emotional Function in Female Mice. Biol Pharm Bull. 2017;40(8):1255-1259.

Nakamoto K, Aizawa F, Miyagi K, Yamashita T, Mankura M, Koyama Y, Kasuya F, Hirasawa A, Kurihara T, Miyata A, Tokuyama S. Dysfunctional GPR40/FFAR1 signaling exacerbates pain behavior in mice. PLoS One. 2017 Jul 19;12(7):e0180610. doi: 10.1371/journal.pone.0180610.

Yuki N, Chan AC, Wong AHY, Inoue T, Yokai M, Kurihara T, Devaux JJ, Wilder-Smith E. Acute painful autoimmune neuropathy: A variant of Guillain-Barre syndrome. Muscle Nerve. 2017 Jul 1. doi: 10.1002/mus.25738.

宮田篤郎. (2017) 薬理学の教育による社会貢献. 日薬理誌第149巻第2号


F. Aizawa, T. Nishinaka, T. Yamashita, K. Nakamoto, T. Kurihara, A. Hirasawa, F. Kasuya, A. Miyata, S. Tokuyama. (2016) GPR40/FFAR1 deficient mice increase noradrenaline levels in the brain and exhibit abnormal behavior. J. Pharmacol. Sci.

栗原 崇. (2016) Trend & Topics 痛みの分子科学−電位依存性Na+チャネル最前線. White - これからの女性医療を考える 4(2):42-8

Yokai M., Kurihara T. and Miyata A. (2016) Spinal astrocytic activation contributes to both induction and maintenance of pituitary adenylate cyclase-activating polypeptide type 1 receptor-induced long-lasting mechanical allodynia in mice. Mol. pain 12.

Ohnou T., Yokai M., Kurihara T., Hasegawa-Moriyama M., Shimizu T., Inoue K., Kambe Y., Kanmura Y. and Miyata A. (2016) Pituitary adenylate cyclase-activating polypeptide type 1 receptor signaling evokes long-lasting nociceptive behaviors through the activation of spinal astrocytes in mice. J. Pharmacol. Sci. 130(4):194-203

Kambe Y, Miyata A. (2016) Mitochondrial c-Fos May Increase the Vulnerability of Neuro2a Cells to Cellular Stressors. J. Mol. Neurosci. 59(1):106-12


栗原 崇, 宮田 篤郎. (2015) 脊髄痛覚伝達における遊離脂肪酸受容体GPR40/FFAR1の関与. 日本薬理学雑誌 146:309-14. PDF

Kambe Y. and Miyata A. (2015) Potential Involvement of Mitochondrial Dysfunction in Major Depressive Disorder: Recent Evidence. Arch. Depression Anxiety 1(1):019-28.

Karki P., Kurihara T., Nakamachi T., Watanabe J., Asada T., Oyoshi T., Shioda S., Yoshimura M., Arita K., Miyata A. (2015) Attenuation of inflammatory and neuropathic pain behaviors in mice through activation of free fatty acid receptor GPR40. Mol. Pain 11:6

Kambe Y. and Miyata A. (2015) Potential involvement of the mitochondrial unfolded protein response in depressive-like symptoms in mice. Neurosci. Lett. 588:166-71


栗原 崇. (2014) 電位依存性Caチャネル. 痛み診療キーポイント. 痛みのScience & Practice (分担執筆) (川真田樹人 編) 文光堂 6:28-9 著書

栗原 崇. (2014) グルタミン酸受容体. 痛み診療キーポイント. 痛みのScience & Practice (分担執筆) (川真田樹人 編) 文光堂 6:42-3

Sugawara H., Tominaga A., Inoue K., Takeda Y., Yamada K. and Miyata A. (2014) Functional Characterization of Neural-Restrictive Silencer Element in Mouse Pituitary Adenylate Cyclase-Activating Polypeptide (PACAP) Gene Expression. J. Mol. Neurosci. 54(3):526-34

Kurihara T., Sakurai E., Toyomoto M., Kii I., Kawamoto D., Asada T., Tanabe T., Yoshimura M., Hagiwara M. and Miyata A. (2014) Alleviation of behavioral hypersensitivity in mouse models of inflammatory pain with two structurally different casein kinase 1 (CK1) inhibitors. Mol. Pain 10(1):17

Bohara M., Kambe Y., Nagayama T., Tokimura H., Arita K. and Miyata A. (2014) C-type natriuretic peptide modulates permeability of the blood-brain barrier. J. Cereb. Blood Flow Metab. 34(4):589-96


Hanada T., Kurihara T., Tokudome M., Tokimura H., Arita K. and Miyata A. (2013) Development and pharmacological verification of a new mouse model of central post-stroke pain. Neurosci. Res. 78:72-80

Miura A., Kambe Y., Inoue K., Tatsukawa H., Kurihara T., Griffin M., Kojima S. and Miyata A. (2013) Pituitary adenylate cyclase-activating polypeptide type 1 receptor (PAC1) gene is suppressed by transglutaminase 2 activation. J. Biol. Chem. 288(45):32720-30

Kimura A., Miyata A. and Honma M. (2013) A combination of in vitro comet assay and micronucleus test using human lymphoblastoid TK6 cells. Mutagenesis. 28(5):583-90.

Horai N., Nagaoka T., Higuchi I., Kasai H., Yoshioka T., Umekita Y., Fukuzaki K., Nagata R., Miyata A. and Abeyama K. (2013) Muscle wasting associated with pathologic change is a risk factor for the exacerbation of joint swelling in collagen-induced arthritis in cynomolgus monkeys. BMC Musculoskelet Disord. 14:205.

Saito H., Nakamachi T., Inoue K., Ikeda R., Kitamura K., Minamino N., Shioda S. and Miyata A. (2013) Autocrine Effects of Neuromedin B Stimulate the Proliferation of Rat Primary Osteoblasts. J Endocrinol. 217(2):141-50.

Mayumi K., Hanioka N., Masuda K., Koeda A., Naito S., Miyata A. and Narimatsu S. (2013) Characterization of marmoset CYP2B6: cDNA cloning, protein expression and enzymatic functions. Biochem. Pharmacol. 85(8):1182-94.


Saito H., Ikeda R., Inoue K., Nagata S., Kitamura K., Minamino N., Kangawa K. and Miyata A. (2012) Neuromedin B stimulates proliferation of mouse chondrogenic cell line ATDC5. Peptides. 36(2):299-302.

Miura A., Odahara N., Tominaga A., Inoue K., Kambe Y., Kurihara T. and Miyata A. (2012) Regulatory mechanism of PAC1 gene expression via Sp1 by nerve growth factor in PC12 cells. FEBS Lett. 586(12):1731-5

Kambe Y. and Miyata A. (2012) Role of Mitochondrial Activation in PACAP Dependent Neurite Outgrowth. J. Mol. Neurosci. 48(3):550-7.

Takenouchi R., Inoue K., Kambe Y. and Miyata A. (2012) N-arachidonoyl glycine induces macrophage apoptosis via GPR18. Biochem. Biophys. Res. Commun. 418(2):366-71.


Narimatsu S, Nakata T, Shimizudani T, Nagaoka K, Nakura H, Masuda K, Katsu T, Koeda A, Naito S, Yamano S, Miyata A, Hanioka N. Regio- and stereoselective oxidation of propranolol enantiomers by human CYP2D6, cynomolgus monkey CYP2D17 and marmoset CYP2D19. Chem Biol Interact. 2011 Feb 1;189(3):146-52.


A. Miyata, S. Shioda and A. Baba, The 9th International Symposium on VIP, PACAP, and Related Peptides. J Mol Neurosci, 2010.

N. Okayama, A. Matsunaga, Y. Kakihana, K. Fujikawa, K. Inoue, T. Nagayama, M. Takeyama, A. Miyata and Y. Kanmura, The effects of the phosphodiesterase inhibitor olprinone on global cerebral ischemia. Anesth Analg, 2010. 110(3): p. 888-894.

A. Tominaga, H. Sugawara, T. Futagawa, K. Inoue, K. Sasaki, N. Minamino, M. Hatakeyama, H. Handa and A. Miyata, Characterization of the testis-specific promoter region in the human pituitary adenylate cyclase-activating polypeptide (PACAP) gene. Genes Cells, 2010. 15(6): p. 595-606.

M. Ushiyama, R. Ikeda, M. Yoshida, K. Mori, K. Kangawa, H. Sugawara, K. Inoue, K. Yamada and A. Miyata, Alternative Splicing of the Pituitary Adenylate Cyclase-activating Polypetide (PACAP) Receptor Contributes to Function of PACAP-27. J Mol Neurosci, 2010.


A. Nagata, T. Tanaka, A. Minezawa, M. Poyurovsky, T. Mayama, S. Suzuki, N. Hashimoto, T. Yoshida, K. Suyama, A. Miyata, H. Hosokawa, T. Nakayama and I. Tatsuno, cAMP activation by PACAP/VIP stimulates IL-6 release and inhibits osteoblastic differentiation through VPAC2 receptor in osteoblastic MC3T3 cells. J Cell Physiol, 2009. 221(1): p. 75-83.


A. Tominaga, H. Sugawara, K. Inoue and A. Miyata, Implication of pituitary adenylate cyclase-activating polypeptide (PACAP) for neuroprotection of nicotinic acetylcholine receptor signaling in PC12 cells. J Mol Neurosci, 2008. 36(1-3): p. 73-78.


S. Iwata, M. Nomoto and A. Miyata, Microarray analysis of laser capture microdissected substantia nigra pars compacta after a single administration of MPTP in common marmosets. Nihon Shinkei Seishin Yakurigaku Zasshi, 2007. 27(4): p. 161-166.

M. Ushiyama, R. Ikeda, H. Sugawara, M. Yoshida, K. Mori, K. Kangawa, K. Inoue, K. Yamada and A. Miyata, Differential intracellular signaling through PAC1 isoforms as a result of alternative splicing in the first extracellular domain and the third intracellular loop. Mol Pharmacol, 2007. 72(1): p. 103-111.


K. Fujikawa, T. Nagayama, K. Inoue, N. Minamino, K. Kangawa, M. Niiro and A. Miyata, C-type natriuretic peptide is specifically augmented by pituitary adenylate cyclase-activating polypeptide in rat astrocytes. Ann N Y Acad Sci, 2006. 1070: p. 282-285.

S. Iwata, H. Morioka and A. Miyata, Classification of antipsychotic drugs by gene expression in the frontal cortex of mice. Nihon Shinkei Seishin Yakurigaku Zasshi, 2006. 26(2): p. 107-109.

M. Ushiyama, H. Sugawara, K. Inoue, K. Kangawa, K. Yamada and A. Miyata, Characterization of the PAC1 variants expressed in the mouse heart. Ann N Y Acad Sci, 2006. 1070: p. 586-590.


S. Iwata, H. Morioka, M. Iwabuchi, K. Shinohara, M. Maeda, T. Shimizu and A. Miyata, Administration of haloperidol with biperiden reduces mRNAs related to the ubiquitin-proteasome system in mice. Synapse, 2005. 56(4): p. 175-184.


H. Hichiya, S. Kuramoto, S. Yamamoto, S. Shinoda, N. Hanioka, S. Narimatsu, K. Asaoka, A. Miyata, S. Iwata, M. Nomoto, T. Satoh, K. Kiryu, N. Ueda, S. Naito, G. T. Tucker and S. W. Ellis, Cloning and functional expression of a novel marmoset cytochrome P450 2D enzyme, CYP2D30: comparison with the known marmoset CYP2D19. Biochem Pharmacol, 2004. 68(1): p. 165-175.

S. Iwata, M. Nomoto, H. Morioka and A. Miyata, Gene expression profiling in the midbrain of striatal 6-hydroxydopamine-injected mice. Synapse, 2004. 51(4): p. 279-286.

A. Miyata, [Tissue distributions and molecular forms of natriuretic polypeptides]. Nippon Rinsho, 2004. 62 Suppl 9: p. 23-27.

A. Miyata, H. Sugawara, S. Iwata, T. Shimizu and K. Kangawa, [The regulatory mechanism for neuron specific expression of PACAP gene]. Nippon Yakurigaku Zasshi, 2004. 123(4): p. 235-242.

T. Shimizu, M. Katahira, H. Sugawara, K. Inoue and A. Miyata, Diverse effects of intrathecal pituitary adenylate cyclase-activating polypeptide on nociceptive transmission in mice spinal cord. Regul Pept, 2004. 123(1-3): p. 117-122.

H. Sugawara, K. Inoue, S. Iwata, T. Shimizu, K. Yamada, N. Mori and A. Miyata, Neural-restrictive silencers in the regulatory mechanism of pituitary adenylate cyclase-activating polypeptide gene expression. Regul Pept, 2004. 123(1-3): p. 9-14.


H. Sano, A. Miyata, T. Horio, T. Nishikimi, H. Matsuo and K. Kangawa, The effect of pituitary adenylate cyclase activating polypeptide on cultured rat cardiocytes as a cardioprotective factor. Regul Pept, 2002. 109(1-3): p. 107-113.



笹栗 俊之・宮田 篤郎 (2018) ベッドサイドの薬理学,丸善出版


栗原 崇. (2014) 電位依存性Caチャネル. 痛み診療キーポイント. 痛みのScience & Practice (分担執筆) (川真田樹人 編) 文光堂 6:28-9

栗原 崇. (2014) グルタミン酸受容体. 痛み診療キーポイント. 痛みのScience & Practice (分担執筆) (川真田樹人 編) 文光堂 6:42-3



TEL 099-275-5256


Powered by Yuki Kambe